Gregory is a devout Catholic who wishes to kill evil people in order to ensure their safe passage to heaven, Gary is an assembly worker at a trophy shop who wishes to murder potential trophy winners, Graham is Gary's intern who will do anything to become a trophy maker, and Vinny Van Go drives a road emergency van solely for the purpose of making friends. A chance encounter compels these four dim-witted misfits to band together and embark on an insane and entirely funny road trip adventure, where they encounter skinheads, fraternity jocks, sorority babes, missing children, bikers, porn stars, clowns, and Kathie Lee Gifford! If the boys are not careful, they may succumb to human nature in what has been dubbed "the world's first serial killer buddy film."