Comedy centering on Dr. George Coleman, a high vet with an impressive collection of famous animal patients at the Crane Animal Hospital - a bustling new york veterinary clinic where it often seems as though the patients have been running the location. Despite his unorthodox personality, George has an indisputable gift except that the individual kind - with creatures of all kinds. Much to his chagrin, George learned that Dorothy Crane, his ex-girlfriend, has inherited the family business and is now George's boss. Challenging and Whipsmart, Dorothy shakes the hospital up as she butts heads and brings order into the chaos.