Twelve-year-old Simone feels painfully disconnected from the planet after watching the brutal death of her mommy. Simone, a multimedia artist in her twenties, is currently trying hard to control her panic disorder and keep at an underground parking lot. Along with a sixty-year-old physicist, Simone, is currently giving a summit on the essence of time. The 3 Simones' lives are merged at a labyrinthine meta-world at which timeframes float, personalities multiply, and also storylines replicate and enlarge. But, for many its shuttling forward and back through time, ENDORPHINE remains grounded at the Simones' inner lives -- it's a study of happenings which poignantly explores how folks deal with injury.