In his basement in San Francisco, boy genius Quinn Mallory unlocks the door to an infinite number of Earths. During a test run, Quinn invites his co-worker Wade Wells and his teacher Professor Maximillian Arturo to see his new invention. But because of an increase in power and an early departure, all three of them and a washed-up soul singer named Rembrandt "Crying Man" Brown are lost in a parallel world. Now, they must "slide" from world to world, adapting to their new surroundings while also trying to get back to their world. Will they ever make it back?