Place in downtown New York in 1900,'The' Knick' is centered upon the groundbreaking surgeons and the Knickerbocker Hospital, nurses and staff who work there, pushing the boundaries of medicine in some time of large mortality rates and also anti antibiotics. John Thackery is a surgeon new methods within the field, despite his covert obsession with cocaine. He also directs a team of doctors including his protégé Dr. Everett Gallinger. The youthful Dr. Bertie Chickering Jr. and Dr. Algernon Edwards, a promising surgeon who's recently been thrust upon him. Captain August Robertson, Cornelia Robertson, the girl of its benefactor is additionally included by the cast of characters at a medical facility. Surly Creek driver Tom Cleary. Lucy Elkins. A fresh-faced nurse against the country. The hospital administrator Herman Barrow. A nun who isn't afraid to speak her thoughts, and Sister Harriet.